We use these expressions to show contrast, when two things seem opposite:
Although / though / even though are followed by a subject + verb
Although it rained, we had fun.
Though I was tired, I went out.
In spite of / despite are followed by a noun, pronoun, or -ing verb
In spite of the rain, we had fun.
Despite being tired, I went out.
TIP:
Use these expressions to connect positive and negative ideas.